Secretory IgA in Urinary Tract Infections

Raised urinary secretory IgA in chronic diarrhoea.

Secretory IgA outputs in urine have been measured in 24 malnourished Gambian children who had been admitted to hospital with chronic diarrhoea and in 43 children from a rural Gambian village. Village children of poor nutritional state (less than or equal to 74% weight for age compared with the National Center for Health Statistics reference curve) had secretory IgA outputs that were only one th...

Urinary secretory IgA after nutritional rehabilitation.

We studied the secretory IgA (sIgA) response of the mucosal urinary tract of malnourished children before and after nutritional rehabilitation. sIgA concentration (mg/l) was determined by ELISA in 187 children aged 3 months to 5 years. The children, who frequented a day care center, were divided into four groups, according to nutritional status: 57 were eutrophic, 49 were undergrown, 57 were mo...

Protection against Mucosal Infections by Secretory IgA

In the past decade, several model systems have been developed to study the details of the production of secretory IgA by the mucosal surface. Until recently, most attention in vaccine research has been directed toward establishing a vigorous systemic (predominantly IgG) humoral immune response to the infectious agent. With the recognition, however, that secretory IgA is overwhelmingly the predo...

urinary tract infections in children

Pediatric urinary tract infections.

Urinary tract infection in the pediatric population can lead to significant morbidity if not treated promptly and appropriately. All first infections may signify possible underlying anatomic or functional abnormality and require imaging of the lower and upper tracts. Accurate diagnosis of UTIs requires a properly collected quantitative urine culture. Treatment should be tailored to the pathogen...